1 Cigarette smoke has sensory effects through nicotinic and TRPA 1 but not 2 TRPV 1 receptors on the isolated mouse trachea and larynx 3 4 Tatjana

1. Title Page 1 Cigarette smoke has sensory effects through nicotinic and TRPA1 but not 2 TRPV1 receptors on the isolated mouse trachea and larynx 3 4 Tatjana I. Kichko, Gerd Kobal, Peter W. Reeh 5 6 Institute of Physiology and Pathophysiology, Friedrich-Alexander-University of 7 Erlangen-Nürnberg, Universitätsstrasse 17, 91054 Erlangen, Germany 8 Altria Client Services Inc., 601 East Jackson Street, Richmond (VA) 23219, USA 9 10 11 12 * Corresponding author: Peter W. Reeh, MD-PhD 13 Contact information: 14 Department of Physiology and Pathophysiology, 15 Friedrich-Alexander-University of Erlangen-Nürnberg, 16 Universitaetsstrasse 17, 17 D-91054 Erlangen, Germany 18 Tel: +4991318522228, 19 Fax: +4991318522497, 20 e-mail: [email protected] 21 22 23 Running Title 24 Cigarette smoke-induced CGRP release in airways 25 26 Articles in PresS. Am J Physiol Lung Cell Mol Physiol (August 21, 2015). doi:10.1152/ajplung.00164.2015